Endocrine Abstracts

Introduction: Parathyroid carcinoma (PC) is a rare endocrine malignancy which accounts for 0.005% of all cancers and less than 1% of primary hyperparathyroidism cases. This uncommon tumor usually occurs during the fifth decade of life, with equal frequency in both sexes, and has an indolent but progressive course. It’s frequently symptomatic and patients may have high values of serum calcium and parathyroid hormone (PTH) with a palpable cervical mass. PC generally occurs ...

Introduction: Musculoskeletal system is widely affected in acromegalic patients which might cause difficulties in the diagnosis and treatment of inflammatory rheumatological diseases. Here, we report coexistent rheumatoid arthritis (RA) in three acromegalic patients presenting with continuing joint and back pain although acromegalic state was in remission.Case 1: A 64 years old female patient with acromegaly and macroadenoma had undergone transsphenoidal...

Introduction: Thyroid carcinoma is common in young women. Radioactive iodine (RAI) therapy has been confirmed as a useful treatment in the management of differentiated thyroid carcinoma (DTC). For women with DTC, the effect of RAI therapy on gonadal and reproductive function is an important consideration. We aimed to evaluate effects of RAI therapy on ovarian function.Method: Women younger than 40 years old and diagnosed with thyroid cancer that required...

Hypertrophic osteoarthropathy (HOA) is a syndrome characterized with proliferation of bones at the distal parts of extremities. Clubbing, periostitis of tubular bones and non-inflammatory arthritis of lower extremities are commonly seen as a part of this syndrome.66 years old male patient was admitted to our hospital with painful swelling of his left lower extremity for 2 months. He denies any other systemic symptoms such as fever and weight loss. He had...

Introduction: Klinefelter syndrome is known as the set of symptoms that result from two or more X chromosomes in males. There is no known association of this syndrome with GH hypersecretion. The most remarkable symptom is gigantism and it can also be observed in androgen deficient states as such as the Klinefelter syndrome and some more genetic syndromes such as the Sotos syndrome, the Marfan syndrome, the homocystinuria, and the fragile X-syndrome. Herein we presente...

Introduction: Premature ovarian failure (POF) is a disorder associated with female infertility, and it affects approximately 1% of women under the age of 40 year. It is considered a multifactorial, heterogeneous condition, for which the exact underlying cause remains unclear. Associations with autoimmune diseases, environmental factors and genetic causes have been described. Herein we presented a case with POF who regained fertility after the treatment of Graves disease.<p...

Introduction: 47,XYY syndrome is characterized by an extra copy of the Y chromosome in each cells of a male. It occurs in about 1/1000 of newborn boys and most males with this syndrome have normal sexual development and fertility. They tend to have tall stature and mild motor and language developmental problems. Testosterone levels are normal. Increased rate of criminal activity in XYY males was related to a lack of judgement and lower socioeconomic status due to a lower mean ...

Introduction: Ocular changes and ocular symptoms may be encountered in patients with hypothyroidism and hyperthyroidism. However, the data concerning the effects of thyroid disorders on intraocular pressure (IOP), central corneal thickness (CCT), and retinal thickness (RT) are very rare. Here, we aimed to evaluate the alterations in IOP, CCT, and RT in patients with euthyroid autoimmune thyroiditis (AIT).Methods: Twenty-five subjects with euthyroid AIT w...

Introduction: Leri–Weill dyschondrosteosis (LWD) is a rare autosomal dominant dyschondrosteosis characterised by Madelung deformity and mesomelic dwarfism. Majority of cases are associated with haploinsufficiency of the short-stature homeobox-containing (SHOX) gene. Here we report a patient with LWD and diabetes mellitus (DM).Case report: A 31 years old man applied with polyuria and polydipsia. He did not have any chronic disease. In family history,...

Introduction: Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by reduced responsiveness of target tissues to thyroid hormone (TH). It is characterized by high serum concentrations of free T4 (Ft4) and usually free T3 (Ft3) accompanied by normal or slightly high serum TSH concentrations. When RTH is suspected, the diagnosis should be confirmed by direct sequencing of the TR-β gene to identify mutations....